We demonstrated that the imaging, behavioral and histological results are closely related. Finally, a “longitudinal” histological study was carried out to highlight the cellular reorganizations occurring after GCI. Then, the learning and memory abilities of control and ischemic (bilaterally or unilaterally) rats were assessed through the olfactory associated learning task.
Hippocampal lesions in ischemic rats were visualized using anatomical Magnetic Resonance Imaging (aMRI). The four-vessel occlusion (4VO) model was performed to produce a transient GCI. This study focused on learning and memory deficits associated with brain neuroanatomical reorganization that appears after GCI. In most cases, patients who survive cardiac arrest develop severe cognitive and motor impairments. Global Cerebral Ischemia (GCI) occurs following cardiac arrest or neonatal asphyxia and leads to harmful neurological consequences.
